International Mentored Scientist Award Program in HIV/AIDS

Project Award Amount $30,000

Description

The CFAR International Mentored Scientist Award seeks to provide a mentored career development opportunity in HIV research for international investigators affiliated with UCSF. Applicants for this award must indicate a UCSF-affiliated faculty research mentor(s) who will commit to guiding the applicant throughout the duration of the proposed project. Project proposals should be geared toward the interests of the applicant (e.g. clinical, basic and/or behavioral-epidemiological research) and focus on HIV research in the investigator’s home country. Our CFAR Science Cores and Working Group are available to assist you in your research (see VII below).

The award level for this program is $30,000 in direct costs plus 8% foreign award indirect costs for one year. Any carry forward is not guaranteed. If this application is awarded, indirect costs at appropriate rates will be added to the total direct costs.

NOTE: Projects must be within NIH’s HIV/AIDS research high or medium priority areas.

NIH does not allow CFAR to fund clinical trials. If you are considering a study involving any clinical or behavioral intervention, please contact (brenda.sanchez@ucsf,edu, cc. lauren.sterling@ucsf.edu) with a brief description of your study to determine whether your proposed project would be eligible for funding through CFAR. If it is not, we will provide advice on alternative funding options.

Applications must be submitted via the RAP website by September 18, 2:00 PM PT. Any questions about proposal submission or review process please contact RAP Staff.

Program Contact

Should you have any questions regarding submission or reporting procedures, please contact Brenda Sanchez, CFAR Core Development Manager, at Brenda.sanchez@ucsf.edu. The complete guidelines for this RFA can be found here: http://cfar.ucsf.edu/sites/cfar.ucsf.edu/files/International-Mentored-Program-2017-CFAR-Guidelines.pdf

ELIGIBILITY

Eligibility requirements need to be met as of date of submission; no waivers are allowed.

Researchers (all levels), post-doctoral fellows, and trainees located at a UCSF-affiliated foreign institution who have not received an NIH R01-equivalent grant in HIV/AIDS. More senior faculty members may apply only if they are newly entering the field of HIV research.

DESIGNATION OF RESEARCH MENTOR

All International Mentored award applications require a faculty research mentor from UCSF or a UCSF-affiliated institution. (http://cfar.ucsf.edu/about/partners). CFAR requires your research mentor’s support to advise and guide the research portion of your application before submitting it to RAP. If no such person has yet been named, the applicant must arrange this before submission of the grant proposal. The mentor should be recognized as an accomplished investigator in AIDS research, and should be able to demonstrate past success in training/mentoring independent investigators. The mentor’s role is to provide oversight on the planning, direction, and execution of the proposed research. In addition, the mentor must commit to mentoring the applicant’s throughout the duration of the research project.

NOTE: Mentor cannot have supervisory authority over the applicant(s) under any circumstance, part-time or full-time, during the project period. If the applicant works in your lab and you are his/her supervisor, you are required to find another person to act as a Research Mentor for the applicant’s project. If questions arise, please contact Lauren Sterling, at Lauren.Sterling@ucsf.edu, CFAR Managing Director.

AWARD RESTRICTIONS

  • Clinical Trials: NIH does not allow CFAR to fund clinical trials. If you are considering a study involving a clinical or behavioral intervention, please contact Brenda Sanchez with a brief description of your study (brenda.sanchez@ucsf.edu, cc: lauren.sterling@ucsf.edu) to determine whether your proposed project would be eligible for funding through CFAR. If it is not, we will provide advice on alternative funding options.
  • International Studies Require NIH Compliance: All International studies conducted in a foreign setting will require additional NIH review and approval. In addition, applicant must have IRB approvals for both local and foreign sites; institutional FWA numbers, and human subjects training certifications (for local and foreign investigators) before funds are released to the awardee via a subcontract. [See NIH checklist form: https://www.niaid.nih.gov/sites/default/files/internationalstudieschecklist.doc.] Once all paperwork has been filed with the NIH, approval takes approximately 8–12 weeks.
  • Human Subjects: All international studies will require both UCSF and local institution IRB approval. Investigators should visit the UCSF CHR website for details on when and how to apply for UCSF CHR approval at http://irb.ucsf.edu. Information on training, including online training resources, can be found on the CHR website at http://irb.ucsf.edu/citi-human-subjects-training.
  • Studies Above Minimal Risk: The NIH requires additional review (clinical checklist) for all studies above minimal risk or in vulnerable populations. https://www.niaid.nih.gov/sites/default/files/cfarguideclinresstud.doc.

CRITERIA FOR REVIEW/EVALUATION OF APPLICATIONS

Completed applications which meet eligibility requirements will be evaluated for scientific and technical merit by an appropriate review committee convened by the UCSF Resource Allocation Program in accordance with NIH review criteria: 1. Significance, 2. Approach, 3. Innovation, 4. Investigator, 5. Environment. Each of these criteria will be addressed and considered in assigning the overall application score.

SELECTION OF AWARDEES

CFAR makes funding decisions based on several factors – scientific review score, alignment of proposal to CFAR/OAR strategic goals, proposal research area of focus, potential for the PI to become an independent investigator, and alignment with other requirements set forth in the RFA.

CFAR RESEARCH RESOURCES
Awardees are encouraged to use one or more support services from our CFAR research resources:

  • Implementation Science Scientific Working Group – Applicants proposing a study in the field of implementation science are required to have an expert from the new Implementation Science Working Group consult with them regarding their study. Send an email with a brief study description to Elvin Geng, SWG Director (elvin.geng@ucsf.edu).
  • Clinical and Population Sciences Core: Steven Deeks, MD & Jeff Martin, MD, MPH, Directors; (SDeeks@php.ucsf.edu; martin@psg.ucsf.edu).
  • Immunology Core: Jeffrey Milush, PhD, Director (Jeffrey.Milush@ucsf.edu)
  • Virology Core: Joseph Wong, MD, Director; (joseph.wong2@va.gov).
  • Specimen Bank Core: Richard Jordan, DDS, PhD & Yvonne DeSouza, MS, Directors (richard.jordan@ucsf.edu,Yvonne.DeSouza@ucsf.edu).
  • Pharmacology Core: Francesca Aweeka, Director (FAweeka@sfghsom.ucsf.edu)
  • Health Disparities Core: Applicants proposing to conduct research with human subjects, especially local and/or underserved communities, are encouraged to consult with the Health Disparities Core. Send an email with a brief study description to Lauren Sterling, Managing Director (lauren.sterling@ucsf.edu) to receive this consultation.

TO APPLY:

Tips for Applying from Abroad: When submitting from a foreign country, make sure you submit well before the deadline to deal with possible local issues black outs, and internet access, etc.) and ensure your application is received on time. RAP will no longer accept applicants submitted after the deadline regardless of any circumstances.

STEP 1) Complete the electronic application form
STEP 2) Upload your proposal as a SINGLE PDF that includes all the things listed in numeric order in the instructions below

Instructions for Proposal PDF

Please write your proposal following the instructions listed below and create one single PDF file.
Proposal Length: Maximum 6 pages, including figures and tables, excluding table of contents and literature cited. Format Requirements: Arial font; 11 pt; minimum 0.5 inch for all margins; no appendices; include page numbers and table of contents.

Resubmissions
Definition: same research topic with an amended application or research plan rather than a new research topic and new research plan.
Requirements: Please use up to one extra page to introduce your revised proposal, addressing the issues raised in the review, and any additional changes to your proposal. A new letter from the Chair is not required if the resubmission is within 2 cycles (one skipped cycle max). You will include the old letter and state your resubmission is within 2 cycles and new letter is not required. Make sure the new changes are highlighted in bold or italic font so the reviewers can easily see where and how the proposal has changed. Do NOT use track changes.

1. Investigator Name (no multiple PIs); only one application is permitted per cycle.

  • Country of citizenship
  • Country of permanent residence

2. Project Title

3. Foreign Country. Supply the following (if applicable):

  • Country
  • Project field site
  • Foreign institution FWA number
  • Foreign IRB date of approval and approval number (specify if pending)

4. Human Subjects - Indicate if human subjects will be used or not. Supply the following:

• IRB date of approval
• IRB approval number
• Specify if pending

5. Animal Subjects - Indicate if Animal subjects will be used or not. Supply the following:

  • IACUC date of approval
  • IACUC approval number
  • Specify if pending

6. Abstract - (one paragraph only, max 300 words summary of project including objective, design, duration of study, and statistical analysis of data).

7. Proposal - (maximum 6 pages, including figures and tables, [a-e below] excluding literature cited, mentoring plan, and additional human-subjects information [f-i below])

  1. Aims (list at least two aims)
  2. Background and Significance
  3. Preliminary studies
  4. Experimental Design and Methods (include time-table)

i) Hypothesis, ii) Rationale, iii) Experimental approach, iv) Interpretation of results

  1. Explain how this pilot project is important for your career goals, e.g., lead to major funding, etc.
  2. Mentoring Plan. Describe the plan for oversight of this project by your mentor(s) including the specific role of your primary mentor named in this application. (not included in the page limit)
  3. Literature cited (not included in the page limit)
  4. Protection of Human Subjects description (if applicable)
  5. Inclusion/Enrollment Table (if applicable for studies proposing human subjects, including existing resources) https://grants.nih.gov/grants/forms/phs-inclusion-enrollment-report.htm

8. Budget - The award level for this program is $30,000 in direct costs for a one-year project period. (Direct expenses must = $30,000). Direct costs may include personnel (salary and fringe benefits), consultant costs, equipment, supplies, travel to perform the study or to present findings from the study, and other expenses. Travel, along with other costs, must be fully justified. For all awards, appropriate indirect costs will be added to the total direct costs.

Note: Any foreign subcontracting institution is limited to 8% indirect costs. All applicants applying from other institutions besides UCSF should contact Frank Fernandez, cc Brenda Sanchez for assistance developing your budget with the appropriate allowable indirect costs.

Please use the NIH PHS 398 form “Page 4: Detailed Budget for Initial Budget Period” (http://grants.nih.gov/grants/funding/phs398/fp4.doc) to prepare your budget. The grid below describes the budget items which are allowable/not allowable for the Mentored Award Program:

International Mentored Science Award Program Budget

Allowable

Not Allowable

PI Salary

X

 

Post Doc Salary

X

 

Administrative Support

 

X

Program Supplies

X

 

Equipment

X

 

Software

X

 

Personal Computers*

X

 

Mailing

X

 

Tuition

X

 

Travel**

X

 

Research Staff Support (e.g. RSA; Lab. Technician)

X

 

Patient Care

 

X

Indirect costs***

X

 

Others Expenses****

X

 

* Computers are only allowable when essential to the conduct of the proposed research. If the computer is planned to be used for other projects / responsibilities in addition to the CFAR project, we require that the cost of the computer be shared with those other project budgets, in accordance with the amount of use anticipated by each project.
** Travel for awardees is allowed only if required to conduct the study or to present findings from this study at a conference (not simply to attend a conference).
*** Budget should include your fully allowable federally-negotiated indirect costs
**** Refer to the UCSF Charging Practices and Guidelines of allowable Expenses:
https://controller.ucsf.edu/quick-reference/contracts-grants-accounting/cost-accounting-standards-cas-guidelines

Note: If chosen for an award, applicants must adhere to NIH policy specifying that the collection of salary support from CFAR NIH funds while simultaneously collecting salary support from an NIH K and/or T32 award is unallowable.

9. Budget Justification: Clearly and fully justify all costs including benefit rates and indirect costs. Please contact us for assistance with your budget and/or sub-contract if you have any questions.

10. NIH Bio-sketch of Principal Investigator(s); Mentor(s), and Co-Investigator(s) (5 page maximum). Bio-sketch of Principal Investigator, UCSF/affiliate Faculty Mentor(s), and co-investigator (s): Use NIH SF424 Biographical Sketch Format page (http://grants.nih.gov/grants/forms/biosketch.htm).

11. Letters of Support – Department Head and Mentors

  1. Department Head / Unit head (should indicate support for the application)
  2. Mentor’s Letter of Support: Include a letter of support from your UCSF-affiliated research mentor that includes the information outlined below:
    1. Specific areas in which mentoring will be provided/mentor’s role in the project
    2. Mentor’s background in mentoring
    3. Describe how the project fits with the mentor’s research agenda and mentees career development
    4. Describe mentor’s working relationship (previous and/or current) with applicant

12. Institutional Letter of Support (If Non UCSF)

Please provide a letter of support from the project site institution with signing official signature. The site/institution should comment on the independence of the applicant and availability of space and other resources for the proposed research.