Posey Family Pediatric Cancer Pilot Award

Project Award Amount: Up to $75,000

This pilot award supports a project in pediatric cancer research. We are interested in a proposal that a) develops new insights into the pathogenesis of cancer or mechanisms that underpin abnormal cellular growth pathways as they directly relate to pediatric cancer, b) explores functional genomic dependencies of common mutations occurring in pediatric cancers with relevance to therapeutic opportunities or c) conducts correlative biology for innovative early phase clinical trials conducted at UCSF. This project is intended to support a wide range of research, including basic or clinical/translational science but must have direct applicability to pediatric cancer.

Each pilot project will have a maximum budget of $75,000. Partial investigator salary support may be requested.

Pilot projects are for one year and may be renewable depending on available funds. Two reports are required: a) a project end report at the end of the funding period; and b) a follow up report 12 months after the project end date. Reports should identify resulting publications and subsequent funding obtained to support expanded/extended projects. Any resulting publication must directly acknowledge the funding agency. In addition, any awardees should expect to present their work to the donors and a small group of senior leaders in the division of Pediatric Hematology Oncology in a yearly meeting.


Eligibility requirement need to be met as of date of submission, no waivers allowed.

Who's Eligible:

UCSF Faculty in any series (Ladder Rank, In Residence, Clinical X, Health Science Clinical, Adjunct) in all ranks (Instructors, Assistant, Associate, Full Professors). Postdocs and Fellows may apply. Appointees to the Professional Research Series may also apply.

Who's Not Eligible:

Residents, Specialists.

Criteria for Review/Evaluation of Applications

Proposals will be evaluated based on the quality of the proposed scientific investigation, the significance of the proposed research for pediatric cancer, the potential of the proposal to lead to future successful NIH grant applications, and the quality and promise of the applicant and the research team.

Pilot projects that involve human subjects will require appropriate human research committee approval or exemption before funding is released.

Selection of Awardees

Funding decisions are made independently by each funding agency based on several factors – scientific review score, alignment of proposal to funder’s strategic goals, proposal research area of focus, and specifically called out eligibility or other requirements like membership in a center, affiliation with a specific school, or relevance to a stated auxiliary topic.


STEP 1) Complete the electronic application form
STEP 2) Upload your proposal as a SINGLE PDF that includes all the things listed in numeric order in the instructions below. Do not include form fields in your PDF document.


Please write your proposal following the instructions listed below and create one single PDF file. Do not include form fields in your PDF document.

Proposal Length: Maximum 6 pages, including figures and tables, excluding table of contents and literature cited.
Format Requirements: Arial font; 11 pt; minimum 0.5 inch for all margins; no appendices; include page numbers and table of contents.

Definition: Same research topic with an amended application or research plan rather than a new research topic and new research plan.
Requirements: Please use up to one extra page to introduce your revised proposal, addressing the issues raised in the review, and any additional changes to your proposal. A new letter from the Chair is not required if the resubmission is within 2 cycles (one skipped cycle max). You will include the old letter and state your resubmission is within 2 cycles and new letter is not required. Make sure the new changes are highlighted in bold or italic font so the reviewers can easily see where and how the proposal has changed. Do not use track changes.

1. P.I. Name(s) - Optionally, you may apply with two PIs. If funded, PI1 will be the primary contact for the award set up and management. If the proposal has multiple PIs, both PI1 and PI2 need to meet the eligibility criteria listed for this grant mechanism. Only one application as PI (PI1 OR PI2) is permitted per cycle.

2. Project Title

3. Proposal (maximum 6 pages, including figures and tables, excluding literature cited)

  • Aims
  • Background and Significance
  • Preliminary studies
  • Experimental Design and Methods (include time-table)
  • Explain how this pilot project is important for your career goals (e.g., lead to major funding, etc.)
  • Mentoring Plan: (required for fellows and junior faculty)
    Please describe the plan for oversight of this project by your mentor(s), including the specific role of your primary mentor named in this application.
  • Literature cited (not included in page limit)

4. Detailed Budget ($75,000 maximum per proposal) and please round up to the nearest thousand (i.e. instead of $74,995 list $75,000).

Use the following form: PHS 398 Form Page 4, "Detailed Budget for the Initial Period": http://grants.nih.gov/grants/funding/phs398/phs398.html
Add the network recharge rates to your budget.

Include the 10% Infrastructure and Operations (I&O) fund assessment in your budget.



Not Allowable

PI Salary *






Post Doc Salary



Administrative Support












Personal Computers












Research Staff Support (e.g.; SRA; Lab Technician)



Patient Care



International Subcontracts



Indirect costs on subcontracts



*NIH base salary cap. Fully justify all requests. Generally, PI partial salary support should not exceed 10% of the budget, anything over 10% must be well justified. Multiple PIs can decide how to distribute that 10% salary support among them (e.g., 5%/5% or 6%/4%).

5. Budget Justification: Clearly and fully justify all costs.

6. NIH Bio-sketch of Principal Investigator(s) and Co-Investigator(s) and UCSF Faculty Mentor(s) (5-page maximum): Use Form (http://grants.nih.gov/grants/funding/424/SF424R-R_biosketchsample_VerC.docx) with other support pages. Include active, pending, and planned proposals. Include percent effort, total direct costs (current year) and potential overlap with the current proposal. Include bio-sketch for both PIs of a multi-PI application.

7. Letter(s) of support: Provide a letter of support from the department chair or other unit head. In addition, for junior investigators, department chairs/unit heads should comment on the independence of the applicant and availability of research space and other resources for the proposed research. Include the letter of support at the end of your PDF proposal and address it to the RAP Committee. If there are multiple (two) PIs, a letter of support is required for both PIs. If PIs are in the same department, the chair can vouch for both PIs in a single letter.