Reproductive and Infertility Research Pilot

Award Amount: $75,000/year for 2 years


The UCSF Center for Reproductive Sciences and the UCSF National Center for Translational Research in Reproduction and Infertility (NCTRI) P50 request proposals for a pilot project award, up to $75,000 direct costs per year (for up to two years). Funding support is provided by the UCSF Department of Obstetrics, Gynecology and Reproductive Sciences and the School of Medicine Dean’s Office, and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under Award Number P50HD055764, Linda C. Giudice, Principal Investigator.

The Program at UCSF is dedicated to stimulate, fund, and guide promising and innovative projects related to research on the role of epigenetics in fertility and infertility - from gametogenesis to embryogenesis to implantation and placentation. The goal of this pilot funding is to encourage innovative research proposals related to reproductive processes and reproductive disorders with a focus on epigenetics from junior faculty investigators in a variety of disciplines and perspectives.

A second year of funding will be considered by the UCSF NCTRI Steering Committee after review of a submitted progress report.

Current NCTRI Sites:

Cornell University

Harvard University

Oregon Health and Science University

University of California, San Diego

University of California, San Francisco

University of Pennsylvania

University of Virginia


Administrative questions may be directed to Theresa Farina at [email protected] or 415-502-4742.

For scientific questions, please feel free to contact Dr. Linda Giudice ([email protected])


Eligibility requirements need to be met as of date of submission; no waivers are allowed.

Who's Eligible:
UCSF Junior Faculty in any series (Ladder Rank, In Residence, Clinical X, Health Science Clinical, Adjunct) at the rank of Instructor or Assistant Professor.

Appointees to the Professional Research Series and to the Librarian Series may apply.

Who's Not Eligible: Residents, Fellows, Postdocs, and Specialists are not eligible.

Criteria for Review/Evaluation of Applications

Completed applications that meet eligibility requirements will be evaluated for scientific and technical merit by an appropriate review committee convened by the UCSF Resource Allocation Program in accordance with NIH review criteria: 1. Significance, 2. Approach, 3. Innovation, 4. Investigator, 5. Environment. Each of these criteria will be addressed and considered in assigning the overall application score.

Pilot projects that involve human and/or animal subjects will require approval by the UCSF Committee on Human Research (CHR) and/or the UCSF Institutional Animal Care and Use Committee (IACUC) before funding is released.

Selection of Awardees
Funding decisions are made independently by each funding agency based on several factors – scientific review score, alignment of proposal to funder’s strategic goals, proposal research area of focus, and specifically called out eligibility or other requirements like membership in a center, affiliation with a specific school or relevance to a stated auxiliary topic.


STEP 1) Complete the electronic application form

STEP 2) Upload your proposal as a SINGLE PDF that includes all the items listed in numeric order in the instructions below. Do not include form fields in your PDF document


Please write your proposal following the instructions listed below and create one single PDF file.

Proposal Length: Maximum 6 pages, including figures and tables, excluding table of contents and literature cited.

Format Requirements: Arial font; 11 pt.; minimum 0.5 inch for all margins; no appendices; include page numbers and table of contents.

Definition: Same research topic with an amended application or research plan rather than a new research topic and new research plan.
Requirements: Please use up to one extra page to introduce your revised proposal, addressing the issues raised in the review, and any additional changes to your proposal. A new letter from the Chair is not required if the resubmission is within 2 cycles (one skipped cycle max). You will include the old letter and state your resubmission is within 2 cycles and new letter is not required. Make sure the new changes are highlighted in bold or italic font so the reviewers can easily see where and how the proposal has changed. Do not use the track changes feature.

1. P.I. Name(s) - Optionally, you may apply with two PIs. If funded, PI1 will be the primary contact for the award set-up and management. If the proposal has multiple PIs, both PI1 and PI2 need to meet the eligibility criteria listed for this grant mechanism. Only one application as PI (PI1 OR PI2) is permitted per cycle. Multiple PI (MPI) plan to be included.

2. Project Title

3. Proposal (maximum 6 pages, including figures and tables, excluding literature cited)

  • NIH R03 format for the Research Plan (SF 424), 6 pages maximum
  • Aims
  • Background and Significance
  • Preliminary studies
  • Experimental Design and Methods (include time-table)
  • Explain how this pilot project is important for your career goals (e.g., lead to major funding, etc.)
  • Mentoring Plan: (required for junior faculty)
    Please describe the plan for oversight of this project by your mentor(s), including the specific role of your primary mentor named in this application.
  • The applicant should also indicate the translational potential of the proposed research.
  • Literature cited (not included in page limit; NIH format required)
  • Authentication statement
  • Data sharing plan
  • All other requirements in the NIH R03 grant application

4. Detailed Budget: $75,000/year for 2 years

Please round up to the nearest thousand (i.e. instead of $148,899 list $149,000).

Use the following form: PHS 398 Form Page 4, "Detailed Budget for the Initial Period":

Add the network recharge rates to your budget.



Not Allowable

PI Salary *



Co-Investigator(s) salary



Post Doc Salary



Administrative Support












Personal Computers












Research Staff Support (e.g. RSA; Lab. Technician)



Patient Care



International Subcontracts**

(CC-CCSG only)


Indirect costs on Subcontracts


*NIH base salary cap. Fully justify all requests. Generally, PI partial salary support should not exceed 10% of the budget, salaries over 10% must be well-justified. Multiple PIs can decide how to distribute the 10% salary support amongst themselves (e.g., 5%/5% or 6%/4%).

5. Budget Justification: Clearly and fully justify all costs.

6. NIH Bio-sketch of Principal Investigator(s) and Co-Investigator(s) and UCSF Faculty Mentor(s) (if applicable) (5 page maximum) 

Use this version: Biosketch Version E. Include biosketches for all PIs of a multi-PI application, and any other key personnel such as Co-Investigator(s) or UCSF Faculty Mentor(s). In section "D. Additional Information", list the relevant recent past, planned, active, and pending proposals, including percent effort and total direct costs (annual), where possible. Include a brief discussion of any potential overlap with the current proposal.

7. Letter(s) of support: Provide a letter of support from the department chair or other unit head. In addition, for junior investigators, department chairs/unit heads should comment on the independence of the applicant and availability of research space and other resources for the proposed research. Include the letter of support at the end of your PDF proposal and address it to the RAP Committee. If there are multiple (two) PIs, a letter of support is required for both PIs. If PIs are in the same department, the chair can vouch for both PIs in a single letter. VIEW SAMPLE