Pilot for Junior Investigators in Basic and Clinical/Translational Sciences

Project Award Amount $30,000

$37,500 if funded by the Cancer Center-Cancer Center Support Grant (CC-CCSG) Developmental Funds
$25,000 if funded by the Alzheimer Disease Research Center (ADRC)

Description
These pilot projects are intended to support a wide range of biomedical research, including fundamental basic science, clinical/translational science, health policy and social science, and population science.

Pilot projects are for one year and not renewable. (Some funding agencies allow for no-cost extensions. This will be clarified in the Award Letter.) All funding agencies require progress reports if an award is received. The number and timing of those reports varies between the agencies. Detailed information about this will appear in the respective funding agencies Award Letter.

Eligibility

Who's Eligible:
Assistant Professors in the early phase of their career and Instructors in all series, including adjunct and professional research may apply. Exceptions must be fully justified. If the proposal has multiple PIs, both PI1 and PI2 need to meet the eligibility criteria listed above for this grant mechanism.

Note - Proposals in the Alzheimer's disease area may be submitted by pre-faculty Fellows. Please note that the ADRC is the only funding agency that will fund applications from fellows.

Note

  • For grants funded by the Cancer Center-MZHF applicants must be Physician-Scientists, Cancer Center Members or be sponsored by a Cancer Center Member. Please address this in any cancer-related proposal.
  • For grants funded by the Cancer Center-CCSG applicants must be Cancer Center Members or Associate Members. Please address this in any cancer-related proposal.

Who's Not Eligible:
Fellows are generally not eligible with the only exception of the ADRC. Specialists are not eligible. Current K scholars are not eligible to receive salary support from CTSI-SOS. K2 awardees are not eligible for CTSI-SOS awards.

Designation of Research Mentor
All pilot award applications from individuals at the Assistant Professor level or below require the designation of a faculty mentor. This should be an individual who has primary responsibility for overseeing the research career development of the applicant.

Criteria for Review/Evaluation of Applications
Projects will be evaluated based on the quality of the proposed scientific investigation, the potential of the proposal to lead to a fully funded independent research grant, and the quality and potential of the applicant and the research team.

More on individual funding agencies
(Please note, this is provided for informational purposes only since the review process is centralized).

  • Academic Senate grants are made available in part through endowment funds allocated to specific areas of research. In addition to general funds, the Committee on Research awards money from endowment funds for these specific areas of research:
    • Heart disease
    • Parkinson's disease
    • Heart disease, cancer, vascular or circulatory disorders, and epilepsy
    • Eye diseases
    • Cancer
    • Stomach ailments
    • Other
      Note: the above categories apply to both research on the specified disease and related areas of focus. For example, "stomach ailments research" can include stomach ulcers research and research into diabetes focusing on stomach disorders or ailments.
  • The Alzheimer's Disease Research Center (ADRC) at the UCSF Memory and Aging Center is supporting two awards ($25,000 each for one year) for promising pilot projects. Applications will be evaluated based on their relevance to Alzheimer's disease and related disorders, as well as their innovation and scientific rigor. The ADRC is the only RAP funding agency that will consider pilot applications from fellows. NOTE: The ADRC considers applications for funding once a year, during the Fall cycle only. Pilot applications submitted during the Spring cycle will not be considered for funding by the ADRC, though they may be eligible for funding by other RAP agencies.  Funded by the NIH, the national Alzheimer's Disease Research Center Project is a large collaborative investigation involving multiple academic institutions. It is designed to integrate basic science and clinical resources in order to investigate the clinical, molecular, neuropathological and neuroimaging features of Alzheimer's disease (AD), non-AD dementias, and mild cognitive impairment. The UCSF ADRC, coordinated by the Memory and Aging Center in the Department of Neurology, promotes novel dementia-related basic biomedical and patient-oriented research. The ADRC uses standardized and novel methods to examine patients and biological specimens, so that new hypotheses can be tested regarding the pathogenesis, diagnosis, and treatment of dementia. Its two overarching aims are: 1) To bridge the gap between laboratory and clinical studies in dementia and aging, and 2) To explore the unique and overlapping symptoms seen in various neurodegenerative diseases. Applications for pilot projects from junior investigators, including fellows, are the preferred target for this RFA.
  • Cancer Center-MZHF (funded by the Mt. Zion Health Fund) provides seed funding to encourage clinical and clinical translational scientists, especially those at the beginning of their research career or established investigators wishing to embark on a new area of study, to initiate promising new projects in cancer research that may enable them to compete successfully for federal research grants. Targeted areas are innovative pilot, phase I/II therapeutic studies and other projects in clinical, health policy, health services, psychosocial and behavioral research that have direct application to the prevention, diagnosis, and treatment of cancer. Pre-clinical or laboratory correlative studies that demonstrate a direct path to the clinic will also be considered. Applicants must be physician-scientists and a Cancer Center member or be sponsored by a Cancer Center member. Investigators who are proposing basic science and population research projects are eligible for funding through the Academic Senate, REAC, and CTSI-SOS.
  • Cancer Center-CCSG (funded by the NCI P30 award) provides seed funding to encourage innovative cancer-related research in a wide range of research areas, including basic science, clinical and translational science, health policy and social science, and population sciences. Priority is given to translational science and to areas that are generally under-represented, such as population sciences. This program supports novel cancer research initiatives which are not currently funded by research grants and which may ultimately lead to new ways of preventing, detecting or treating cancer. Emphasis is placed on innovative projects, and applicants must be a Cancer Center Member or Associate Member. Training costs and routine equipment purchases are not allowable.
  • CTSI-SOS requires that the proposal meet CTSI criteria of translational science.
    Note - CTSI-SOS cannot fund any international projects or expenses and cannot fund K2 awardees nor provide salary support to current K scholars.
  • REAC funds pilot projects ranging from basic to clinical and translational. Pilot research should collect data for publication and to acquire successful subsequent funding by other mechanisms. Only School of Medicine faculty qualify for REAC funds.

 

Instructions

Please write your proposal following the instructions listed below:

Proposal Length: Maximum 6 pages, including figures and tables, excluding table of contents and literature cited.
Format Requirements:  Arial font; 11 pt; minimum 0.5 inch for all margins; no appendices; include page numbers and table of contents.

Note Eligibility:

  • Assistant Professors in the early phase of their career and Instructors in all series, including adjunct and professional research may apply. Exceptions must be fully justified.
  • Investigators at CTSI affiliated institutions may apply with documentation of a faculty-equivalent appointment.
  • For grants targeted to the Cancer Center, the PI must either be a Cancer Center Member or be sponsored by a Cancer Center Member.
  • Pre-Fellows with proposals in the Alzheimer's disease area are welcome to apply. Please note that the ADRC is the only funding agency that will consider applications from fellows for this pilot.

Please create one single PDF file including all of the following information:

  1. Grant Mechanism
  2. P.I. Name(s) - Optionally, you may apply with two PIs. If choosing that option, include all information for both PIs (PI1 and PI2); if funded, PI1 will be the primary contact for the award set up and management. If the proposal has multiple PIs, both PI1 and PI2 need to meet the eligibility criteria listed for this grant mechanism.
  • Title
  • Department/Affiliation
  • Email address
  • Phone
  1. PI 1 (contact PI) Grant Administrator (Indicate a post-award financial analyst in your Dept. that will help you manage this grant and be our main contact if you are awarded)
  • Titles
  • Department/Affiliation
  • Email address
  • Phone
  1. Research Mentor(s)
  • Titles
  • Department/Affiliation
  • Email address
  • Phone
  1. Specify if you have been funded as a PI or as a co-investigator in the past 5 years by any of the following UCSF agencies: List titles of grants in detail. Include enough information to allow RAP to understand their content. Specify dollar amounts awarded and source of funds.
  1. Project Title
  2. Amount Requested: $
  3. Abstract (one paragraph only, max 300 words)
  4. Proposal (maximum 6 pages, including figures and tables, excluding literature cited)
  • Aims
  • Background and Significance
  • Preliminary studies
  • Experimental Design and Methods (include time-table)
  • Explain how this pilot project is important for your career goals (e.g., lead to major funding, etc.)
  • Mentoring Plan: Please describe the plan for oversight of this project by your mentor(s), including the specific role of your primary mentor named in this application.
  • Literature cited (not included in page limit)
  1. Co-Investigator(s) (max five) need to have a faculty appointment (only exception is the ADRC)
  • Titles
  • Department/Affiliation
  • Email address
  • Phone
  1. Human Subjects.  Indicate if Human Subjects will be used or not. Supply the following:
  • CHR (IRB) date of approval
  • CHR (IRB) approval number
  • Specify if pending
  1. Human Stem Cells.  Indicate if Human Stem Cell will be used or not. Supply the following:
  • GESCR date of approval
  • GESCR approval number
  • Specify if pending
  1. Animal Subjects.  Indicate if Animal Subjects will be used or not. Supply the following:
  • IACUC date of approval
  • IACUC approval number
  • Specify if pending
  1. Budget ($30,000 maximum per proposal)
    ($37,500 if funded by the CC-CCSG)
    ($25,000 if funded by the ADRC)
    Use the following form: PHS 398 Form Page 4, "Detailed Budget for the Initial Period": http://grants.nih.gov/grants/funding/phs398/phs398.html
    Add the network recharge rates to your budget.

 

Allowable

Not Allowable

PI Salary *

X

 

Post Doc Salary

X

 

Administrative Support

 

X

Supplies

X

 

Equipment

X

 

Software

X

 

Personal Computers

 

X

Mailing

 

X

Tuition

 

X

Travel

 

X

Research Staff Support (e.g. RSA; Lab. Technician)

X

 

Patient Care

 

X

International Subcontracts

 

X (SOS)

Indirect costs on subcontracts

 

X (SOS)

*NIH base salary cap. Fully justify all requests. Generally PI partial salary support should not exceed 10%. Multiple PIs can decide how to distribute that 10% salary support among them (e.g., 5%/5% or 6%/4%).

Notes on specific funding programs:

CTSI-SOS cannot fund any international projects or expenses. Current K scholars are not eligible to receive salary support under this mechanism. K scholars must submit the type of K award received and award dates. Current K scholars must also submit justification for the differences between K-awarded project and RAP project.K2 awardees are not eligible.

Cancer Center-CCSG Developmental Funds cannot support training costs and routine equipment purchases.

  1. Budget Justification: Clearly justify all costs fully.
  2. NIH Bio-sketch of Principal Investigator(s) and Co-Investigator(s) and UCSF Faculty Mentor(s) (4 page maximum): Use Form "PHS 398/2590" from the NIH grant applications (http://grants.nih.gov/grants/funding/phs398/biosketch.doc) with other support pages. Include active, pending, and planned proposals. Include percent effort, total direct costs (current year) and potential overlap with the current proposal. Include bio-sketch for both PIs of a multi-PI application.
  3. Letter(s) of support: Provide a letter of support from the department chair or other unit head. In addition, for junior investigators, department chairs/unit heads should comment on the independence of the applicant and availability of research space and other resources for the proposed research. Include the letter of support at the end of your PDF proposal and address it to the RAP Committee. If there are multiple (two) PIs, a letter of support is required for both PIs. If PIs are in the same department, the chair can vouch for both PIs in a single letter. VIEW SAMPLE

Fill out the electronic application form and upload your proposal PDF