Alzheimer Disease Research Center (ADRC) Developmental Projects

Project Award Amount $75,000/year for 2 years

The ADRC considers applications for funding once a year, during the Fall Cycle only.

Pilot applications submitted during the Spring cycle will not be considered for funding by the ADRC, though they may be eligible for funding by other RAP agencies

Description
The ADRC will be funding one “Developmental Project” per year, at the Fall RAP application cycle. Each project will be funded for 2 years at $75,000/year, for a total of $150,000 for the project.

These projects are intended to support a wide range of biomedical research in the field of Alzheimer’s disease and related disorders (ADRD), including fundamental basic science, clinical/translational science, health policy and social science, and population science. This mechanism is particularly geared towards supporting early career investigators, and is intended to provide adequate funding to establish a new line of investigation, such as a pilot study or the initial data collection or analysis required to promote an innovative hypothesis. They are designed for postdoctoral or junior faculty level investigators, but may be awarded to a more senior investigator whose research is primarily in areas other than ADRD research, but who wants to work in the dementia research field and try a new hypothesis, method, or approach that is not an extension of ongoing ADRD research. The goal is for the recipient to use this award to develop their research program adequately to be in a position to obtain NIH-level research funding and further solidify their career trajectory in the ADRD domain.

Examples of possible developmental projects are:

  • A study based on data in the NACC data set to determine the feasibility of conducting larger studies in the future.
  • A study proposed by a new investigator, with an interest in research in AD, before the study has developed to the point of being suitable to apply for individual grant support.
  • Functional, mechanistic, or pre-clinical activities designed to move a basic discovery towards a translational endpoint in the near future.

Examples of unacceptable developmental projects are:

  • A clinical trial.
  • A study by an Associate Professor who has had previous funding in the ADRD field in the past 10 years.

Developmental projects are for two years and not renewable. A progress report is required 3 months prior to the end of the funding period and one year later, identifying resulting publications and subsequent funding obtained to support the expanded/extended projects. Any resulting publication must directly acknowledge the funding agency.

Eligibility

NOTE: Eligibility requirements need to be met as of date of submission; no waivers are allowed.

Who's Eligible:
UCSF Faculty in any Series (Ladder Rank, In Residence, Clinical X, Health Science Clinical, Adjunct) in the rank of Instructors and Assistant Professors in the early phase of their career may apply. Associate Professors may be considered if they meet the above criteria for an appropriate developmental project.

Appointees to the Professional Research Series and Librarian Series are eligible.

Fellows and Postdoctoral Scholars may also apply.

Designation of Research Mentor
All developmental award applications from individuals at the Assistant Professor level or below require the designation of a faculty mentor. This should be an individual who has primary responsibility for overseeing the research career development of the applicant.

Criteria for Review/Evaluation of Applications
Projects will be evaluated based on the quality of the proposed scientific investigation, the significance of the proposed research for the field of neuroscience/dementia and overall public health, the potential of the proposal to lead future NIH grant applications, and the quality and potential of the applicant and the research team.

Projects that involve human subjects will require human research committee approval before funding is released.

More on the funding agency:

The Alzheimer's Disease Research Center (ADRC) at the UCSF Memory and Aging Center is supporting one award per year ($75,000/year each for two years) for promising developmental projects. Funded by the NIH, the national Alzheimer's Disease Research Center Project is a large collaborative investigation involving multiple academic institutions. It is designed to integrate basic science and clinical resources in order to investigate the clinical, molecular, neuropathological and neuroimaging features of Alzheimer's disease (AD), non-AD dementias, and mild cognitive impairment. The UCSF ADRC, coordinated by the Memory and Aging Center in the Department of Neurology, promotes novel dementia-related basic biomedical and patient-oriented research. The ADRC uses standardized and novel methods to examine patients and biological specimens, so that new hypotheses can be tested regarding the pathogenesis, diagnosis, and treatment of dementia. Its two overarching aims are: 1) To bridge the gap between laboratory and clinical studies in dementia and aging, and 2) To explore the unique and overlapping symptoms seen in various neurodegenerative diseases.

Selection of Awardees
Funding decisions are made independently by each funding agency based on several factors – scientific review score, alignment of proposal to funder’s strategic goals, proposal research area of focus, and specifically called out eligibility or other requirements like membership in a center, affiliation with a specific school or relevance to a stated auxiliary topic.

TO APPLY:

STEP 1) Complete the electronic application form.
STEP 2) Upload your proposal as a SINGLE PDF that includes all the things listed in numeric order in the instructions below. Do not include form fields in your PDF document


INSTRUCTIONS FOR PROPOSAL PDF

Please write your proposal following the instructions listed below and create one single PDF file. Do not include form fields in your PDF document.

Proposal Length: Maximum 6 pages, including figures and tables, excluding table of contents and literature cited.
Format Requirements: Arial font; 11 pt; minimum 0.5 inch for all margins; no appendices; include page numbers and table of contents.

Resubmissions
Definition: Same research topic with an amended application or research plan rather than a new research topic and new research plan.
Requirements: Please use up to one extra page to introduce your revised proposal, addressing the issues raised in the review, and any additional changes to your proposal. A new letter from the Chair is not required if the resubmission is within 2 cycles (one skipped cycle max). You will include the old letter and state your resubmission is within 2 cycles and new letter is not required. Make sure the new changes are highlighted in bold or italic font so the reviewers can easily see where and how the proposal has changed. Do not use track changes.

1. P.I. Name (no multiple PIs)

2. Project Title

3. Proposal (maximum 6 pages, including figures and tables, excluding literature cited)

  • Aims
  • Background and Significance
  • Preliminary studies
  • Experimental Design and Methods (include time-table)
  • Explain how this pilot project is important for your career goals (e.g., lead to major funding, etc.)
  • Mentoring Plan: Please describe the plan for oversight of this project by your mentor(s), including the specific role of your primary mentor named in this application.
  • Literature cited (not included in page limit)

4. Detailed Budget

$75,000/year for 2 years

Use the following form: PHS 398 Form Page 4, "Detailed Budget for the Initial Period": http://grants.nih.gov/grants/funding/phs398/phs398.html. Add the network recharge rates to your budget.

 

Allowable

Not Allowable

PI Salary *

X

 

Co-Investigator(s)

X

 

Post Doc Salary

X

 

Administrative Support

 

X

Supplies

X

 

Equipment

 

X

Software

X

 

Personal Computer

 

X

Mailing

 

X

Tuition

 

X

Travel

 

X

Research Staff Support (e.g. RSA; Lab. Technician)

X

 

Patient Care

 

X

International Subcontractors

 

X

Indirect Cost on Subcontractors

 

X

*NIH base salary cap. Fully justify all requests. Generally PI partial salary support should not exceed 10% of the budget, anything over 10% must be well justified.

6. Budget Justification: Clearly justify all costs fully.

7. NIH Bio-sketch of Principal Investigator(s) and Co-Investigator(s) and UCSF Faculty Mentor(s) (5 page maximum):

Use this version: Biosketch Version E. Include biosketches for all PIs of a multi-PI application, and any other key personnel such as Co-Investigator(s) or UCSF Faculty Mentor(s). In section "D. Additional Information", list the relevant recent past, planned, active, and pending proposals, including percent effort and total direct costs (annual), where possible. Include a brief discussion of any potential overlap with the current proposal.

8. Letter(s) of support: Provide a letter of support from the department chair or other unit head. In addition, for junior investigators, department chairs/unit heads should comment on the independence of the applicant and availability of research space and other resources for the proposed research. Include the letter of support at the end of your PDF proposal and address it to the RAP Committee. VIEW SAMPLE